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Cannabis strains with relatively high CBD:THC ratios are less likely to induce anxiety than vice versa. This may be due to CBD's antagonistic effects at the cannabinoid receptors, compared to THC's partial agonist effect. CBD is also a 5-HT 1A receptor agonist, which may also contribute to an anxiolytic-content effect. 10 Facts About Cannabidiol (CBD) - Leaf Science CBD, or cannabidiol, is a compound in marijuana that offers many benefits without any high. Most people have heard of THC, which is the ingredient in marijuana responsible for the high. But recently, attention has shifted to another compound in marijuana called CBD.
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